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About Hyaluronic Acid

  • Categories:NEWS
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  • Time of issue:2021-04-16
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(Summary description)Hyaluronic Acid is widely used in animal tissue interstitium and ocular vitreous body. By increasing the liquid viscosity of Hyaluronic Acid prolong drug on the surface of the eye, residence time, improve the bioavailability of drugs, reduce drug to eye irritation, increase lubricity and comfortability of eye drops.

About Hyaluronic Acid

(Summary description)Hyaluronic Acid is widely used in animal tissue interstitium and ocular vitreous body. By increasing the liquid viscosity of Hyaluronic Acid prolong drug on the surface of the eye, residence time, improve the bioavailability of drugs, reduce drug to eye irritation, increase lubricity and comfortability of eye drops.

  • Categories:NEWS
  • Author:
  • Origin:
  • Time of issue:2021-04-16
  • Views:0
Information

Hyaluronic Acid Eye drop grade

Hyaluronic Acid is widely used in animal tissue interstitium and ocular vitreous body. By increasing the liquid viscosity of Hyaluronic Acid prolong drug on the surface of the eye, residence time, improve the bioavailability of drugs, reduce drug to eye irritation, increase lubricity and comfortability of eye drops. Hyaluronic Acid is biocompatible with eye tissue and Produce oral preparation or parenteral preparation. It can be used in eye drops, drug carrier, contact lens solutions, topical preparation for wound or burn healing, medical lubricants. but  not including intra-articular and intra-articular preparation.

A. Bacteriostatic effect of Hyaluronic Acid eye drops

Under normal circumstances, the natural presence of Hyaluronic Acid forms a membrane covering the surface of the corneal endothelium, and both the animal and human corneal endothelium have ha-binding sites. Drugs containing Hyaluronic Acid can attach to the surface of the eyeball for a long time, which is conducive to the sustained and effective absorption of drugs by eye tissues. In this way, the anti-inflammation and antibacterial effect of drugs can be fully and effectively played, and the local harmful bacteria cannot grow, which is of great significance in eliminating infection and local stimulation.

B. The therapeutic effect of Hyaluronic Acid on ocular dryness

The researchers examined the water retention of Hyaluronic Acid. It was found that sodium hyaluronate can enhance the water retention of the corneal surface and thus increase the moisture retention of the cornea. Therefore, Hyaluronic Acid eye drops can also be used in the treatment of eye dryness. Hyaluronic Acid can relieve various dry eyes by inhibiting tear film rupture. Using tear film stability as a parameter, 12 volunteers were tested for tear film rupture time and the concentration - effect relationship of Hyaluronic Acid was discussed. The results showed that only when the concentration of Hyaluronic Acid solution reached at least 0.1% could the dry eyes be effectively relieved.

Eye drop grade hyaluronic acid use for

1.Medical beauty

2.eye drops

3.medical lubricants

4.drug carriers

5.microneedle therapy

 

Item

Eye Drop Grade

Appearance

White Powder

Glucuronic Acid

≥45.0%

Hyaluronic Acid

95.0%~105.0%

Absorbance

≤0.25(A257nm),≤0.15(A280nm)

pH

6.0~7.5

Protein

≤0.1%

Intrinsic Viscosity

≥1600(Dry Basis)

Residue on Ignition

≤15.0%

Loss on Drying

≤8.0%

Heavy metal

≤20ppm

Arsenic

≤20ppm

Bacterial Endotoxins

<0.5 IU/mg

Total Plate Count

10cfu/g

Molds & Yeast

<10cfu/g

Staphylococcus aureus

Negative

Pseudomonas Aeruginosa

Negative

Reference Dosage

0.05%~0.5%

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